Welcome to Dresden Stem Cell Lab!

Publications

 

Selected publications

Kräter M, Jacobi A, Tietze S, Wobus M, Werner C, Chavakis T, and Bornhauser, M: Cell-derived Bone marrow-mimetics induce erythroid lineage commitment of hematopoietic stem and progenitor cells ex-vivo. Matters. 2017 doi:10.19185/matters.201709000004

Arulmozhivarman G*, Kräter M*, Wobus M, Friedrichs J, Bejestani E, Müller K, Lambert K, Alexopoulou D, Dahl A, Stöter M, Bickle M, Shayegi N, Hampe J, Stölzel F, Brand M, von Bonin M*, Bornhauser, M*: Zebrafish In-Vivo Screening for Compounds Amplifying Hematopoietic Stem and Progenitor Cells: – Preclinical Validation in Human CD34+ Stem and Progenitor Cells. Scientific Reports. 2017 doi:10.1038/s41598-017-12360-0 (* authors contributed equally)

Kräter M*, Jacobi A*, Otto O, Tietze S, Müller K, Poitz DM, Palm S, Zinna VM, Biehain U, Wobus M, Chavakis T, Werner C, Guck J and Bornhauser, M: Bone marrow niche-mimetics modulate HSPC function via integrin signaling. Scientific Reports. 2017 doi:10.1038/s41598-017-02352-5 (* authors contributed equally)

Arulmozhivarman G, Stöter M, Bickle M, Kräter M, Wobus M, Ehninger G, Stölzel F, Brand M, Bornhäuser M and Shayegi N: In Vivo Chemical Screen in Zebrafish Embryos Identifies Regulators of Hematopoiesis Using a Semiautomated Imaging Assay. Journal of Biomolecular Screening. 2016

Stölzel F, Mohr B, Kramer M, Oelschlägel U, Bochtler T, Berdel WE, Kaufmann M, Baldus CD, Schäfer-Eckart K, Stuhlmann R, Einsele H, Krause SW, Serve H, Hänel M, Herbst R, Neubauer A, Sohlbach K, Mayer J, Middeke JM, Platzbecker U, Schaich M, Krämer A, Röllig C, Schetelig J, Bornhäuser M, Ehninger G: Karyotype complexity and prognosis in acute myeloid leukemia. Blood Cancer J 2016.

Wobus M, Bornhäuser M, Jacobi A, Kräter M, Otto O, Ortlepp C, Guck J, Ehninger G, Thiede C, Oelschlägel U: Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia. Oncotarget 2015

Shayegi N, Meyer C, Lambert K, Ehninger G, Brand M, Bornhäuser M: CXCR4 blockade and Sphingosine-1-phosphate activation facilitate engraftment of haematopoietic stem and progenitor cells in a non-myeloablative transplant model. Br J Haematol 2013.

Lenk J, Bornhäuser M, Kramer M, Holig K, Poppe-Thiede K, Schmidt H, Wiesneth M, Schaefer-Eckart K, Schlenke P, Punzel M, Martin S, Kroschinsky F, Schmidt AH, Ehninger G, Thiede C: Sex and body mass index but not CXCL12 801 G/A polymorphism determine the efficacy of hematopoietic cell mobilization: a study in healthy volunteer donors. Biol Blood Marrow Transplant 2013;19:1517-1521.

Prewitz MC, Seib FP, von BM, Friedrichs J, Stissel A, Niehage C, Muller K, Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C: Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments. Nat Methods 2013;10:788-794.

Duryagina R, Thieme S, Anastassiadis K, Werner C, Schneider S, Wobus M, Brenner S, Bornhäuser M: Overexpression of jagged-1 and its intracellular domain in human mesenchymal stromal cells differentially affect the interaction with hematopoietic stem and progenitor cells. Stem Cells Dev 2013;22:2736-2750.

Ferrer RA, Wobus M, List C, Wehner R, Schonefeldt C, Brocard B, Mohr B, Rauner M, Schmitz M, Stiehler M, Ehninger G, Hofbauer LC, Bornhäuser M, Platzbecker U: Mesenchymal stromal cells from patients with myelodyplastic syndrome display distinct functional alterations that are modulated by lenalidomide. Haematologica 2013;98:1677-1685.

von Bonin M, Wermke M, Cosgun KN, Thiede C, Bornhäuser M, Wagemaker G, Waskow C: In vivo expansion of co-transplanted T cells impacts on tumor re-initiating activity of human acute myeloid leukemia in NSG mice. PLoS One 2013;8:e60680.

Fasslrinner F, Wobus M, Duryagina R, Muller K, Stopp S, Wehner R, Rauner M, Hofbauer LC, Schmitz M, Bornhäuser M: Differential effects of mixed lymphocyte reaction supernatant on human mesenchymal stromal cells. Exp Hematol 2012;40:934-944.

Stopp S, Bornhäuser M, Ugarte F, Wobus M, Kuhn M, Brenner S, Thieme S: Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells. Haematologica 2013;98:505-513.

Hofmann AD, Beyer M, Krause-Buchholz U, Wobus M, Bornhäuser M, Rodel G: OXPHOS supercomplexes as a hallmark of the mitochondrial phenotype of adipogenic differentiated human MSCs. PLoS One 2012;7:e35160.

Jing D, Wobus M, Poitz DM, Bornhäuser M, Ehninger G, Ordemann R: Oxygen tension plays a critical role in the hematopoietic microenvironment in vitro. Haematologica 2012;97:331-339.

Goedecke A, Wobus M, Krech M, Munch N, Richter K, Holig K, Bornhäuser M: Differential effect of platelet-rich plasma and fetal calf serum on bone marrow-derived human mesenchymal stromal cells expanded in vitro. J Tissue Eng Regen Med 2011;5:648-654.

Niehage C, Steenblock C, Pursche T, Bornhäuser M, Corbeil D, Hoflack B: The cell surface proteome of human mesenchymal stromal cells. PLoS One 2011;6:e20399.

Bauer N, Wilsch-Brauninger M, Karbanova J, Fonseca AV, Strauss D, Freund D, Thiele C, Huttner WB, Bornhäuser M, Corbeil D: Haematopoietic stem cell differentiation promotes the release of prominin-1/CD133-containing membrane vesicles–a role of the endocytic-exocytic pathway. EMBO Mol Med 2011;3:398-409.

Bornhäuser M, Thiede C, Platzbecker U, Kiani A, Oelschlaegel U, Babatz J, Lehmann D, Holig K, Radke J, Tuve S, Wermke M, Wehner R, Jahnisch H, Bachmann MP, Rieber EP, Schetelig J, Ehninger G, Schmitz M: Prophylactic transfer of BCR-ABL-, PR1-, and WT1-reactive donor T cells after T cell-depleted allogeneic hematopoietic cell transplantation in patients with chronic myeloid leukemia. Blood 2011;117:7174-7184.

Fonseca AV, Freund D, Bornhäuser M, Corbeil D: Polarization and migration of hematopoietic stem and progenitor cells rely on the RhoA/ROCK I pathway and an active reorganization of the microtubule network. J Biol Chem 2010;285:31661-31671.

Bornhäuser M, Aringer M, Thiede C: Mixed lymphohematopoietic chimerism and response in Wegener’s granulomatosis. N Engl J Med 2010;362:2431-2432.

Jing D, Fonseca AV, Alakel N, Fierro FA, Muller K, Bornhäuser M, Ehninger G, Corbeil D, Ordemann R: Hematopoietic stem cells in co-culture with mesenchymal stromal cells–modeling the niche compartments in vitro. Haematologica 2010;95:542-550.

Seib FP, Lanfer B, Bornhäuser M, Werner C: Biological activity of extracellular matrix-associated BMP-2. J Tissue Eng Regen Med 2010;4:324-327.

Seib FP, Prewitz M, Werner C, Bornhäuser M: Matrix elasticity regulates the secretory profile of human bone marrow-derived multipotent mesenchymal stromal cells (MSCs). Biochem Biophys Res Commun 2009;389:663-667.

Seib FP, Muller K, Franke M, Grimmer M, Bornhäuser M, Werner C: Engineered extracellular matrices modulate the expression profile and feeder properties of bone marrow-derived human multipotent mesenchymal stromal cells. Tissue Eng Part A 2009;15:3161-3171.

Seib FP, Franke M, Jing D, Werner C, Bornhäuser M: Endogenous bone morphogenetic proteins in human bone marrow-derived multipotent mesenchymal stromal cells. Eur J Cell Biol 2009;88:257-271.

von Bonin M, Stolzel F, Goedecke A, Richter K, Wuschek N, Holig K, Platzbecker U, Illmer T, Schaich M, Schetelig J, Kiani A, Ordemann R, Ehninger G, Schmitz M, Bornhäuser M: Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium. Bone Marrow Transplant 2009;43:245-251.