We are associated with the Hematology department (Medizinische Klinik und Poliklinik I) located within the Medical Campus of the Technical University of Dresden.
As part of the Excellence Cluster and Centre for Regenerative Therapies Dresden and the Collaborative Research Grant 655 ‘From cells to tissues’ our lab focuses on the biology and function of hematopoietic (HSC) and mesenchymal stem cells (MSC). Defined subsets of multipotent stem cells derived from primary human sources (blood, bone marrow or cord blood) are studied in various functional and molecular aspects.
One of the most frequently used models is the coculture of HSC and MSC with respect to its potential clinical relevance and the option to study stem cell niches in-vitro. In parallel, we try to address analogies between leukemic and normal HSC with regard to their interaction with the environmental cues (stromal cells, ECM etc.) A variety of techniques to characterize human HSC and MSC are available (Microscopy including Fluorescent and confocal imaging, FACS, clonogenic assays, transmigration assays, molecular techniques etc.). Specific projects address the role of micro RNAs in MSC and/or HSC. One specific aspect of our research is the collaboration with experts in biomaterial science at the Max-Bergmann Centre with respect to the use of artificial scaffolds to mimic stem cell niches.
If you are interested in a specific project, are looking for a PhD or Postdoc position or want to set up a collaborative project do not hesitate to contact us.
With best regards!
Prof. Dr. Martin Bornhäuser