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Mesenchymal stem cells (MSC)

Mesenchymal stem cells (MSC) locate in the bone marrow, are multipotent non-hematopoietic progenitor cells that differentiate into osteoblasts, adipocytes, chondrocytes, tenocytes and other connective tissues. MSC do not express hematopoietic markers, but a pattern of mesenchymal molecules, such as CD73, CD90, CD105, CD146 and CD166. MSC have been described to interact with HSC influencing their homing, proliferation and differentiation through cell-cell contact and production of soluble factors. MSC can be co-transplanted with HSC to improve their engraftment in bone marrow and may be used to repair damaged bone and cartilage. MSC have also been recently described as strong immunosuppressors.

Author: Fernando A. Fierro