Hematopoietic stem/progenitor cells (HSC/HPC)
Hematopoietic stem cells (HSC), are characterized by their potential to reconstitute the whole blood system of recipients after allogeneic or autologous transplantation. In clinic, HSC transplantation is today a very well established treatment modality. Using HSC specific markers, such as CD34 and CD133, researchers are able to directly isolate them from bone marrow, peripheral blood after HSC mobilization, or cord blood, which is a new HSC source becoming more and more popular in recent years. In our lab, we are interested in the biological properties of human HSC based on clinical questions, such as ex vivo expansion of HSC and stem cell fate regulation by microenvironmental components.
Author: Fernando A. Fierro